From Hawaii 5-0 to Magnum PI to Lost, Hawaii's beautiful scenery has acted as a backdrop to various entertainment shows. But, as far as I know, Atari's new "Test Drive Unlimited" [warning: Flash and popups required] is the first online multi-player game set entirely on Oahu. Versions for Xbox 360, Playstation 2, PSP, and Windows are due out over the next two months.
I'm not much of gamer, but if you are into virtual car racing, this might be to a game to, uh, test drive. YMMV. Insert disclaimer here.
Aloha!